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The RoslinCT lab, which specialises in cell and gene therapies, is helping to manufacture the therapy on behalf of US firm Vertex.
A gene-editing treatment called Casgevy has been authorised by the MHRA and is being produced in Edinburgh.
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Zosurabalpin defeated highly drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab) in mouse models of pneumonia and sepsis, and was being tested in human trials.
Antibiotic-resistant infections pose an urgent threat to human health – particularly those caused by a large group of bacteria known as Gram-negative bacteria, which are protected by an outer shell containing a substance called lipopolysaccharide (LPS).
While he stressed that this molecule alone would not solve the public health threat of antimicrobial resistant infections, the discovery could lay the foundations for future efforts to drug the same transport system in other bacteria.
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Meanwhile, the UK’s science, innovation and technology committee has called for steps to develop the potential of bacteria-killing viruses – called bacteriophages – that could provide an alternative to antibiotics for resistant infections.
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Group of Seven
once known as the Algonquin School
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What to use instead of MD5
NIST’s current recommendation is the SHA3 family. It does not have any of the flaws that MD5 does, and works just as well.
If speed is a particular concern, perhaps with very large files, Blake3 is one of the fastest algorithms.
Do not use SHA1, which is also broken.
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Picatrix
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